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pentobarbital will decrease the level or impact of fedratinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Effect of coadministering a robust CYP3A4 inducer with fedratinib hasn't been researched.pentobarbital will lower the extent or result of levamlodipine by affecting hepatic/intestinal enzyme CYP3A4